Alberto Kornblihtt: Coupling alternative splicing with transcription
نویسنده
چکیده
Kornblihtt studies how gene expression is controlled in mammals and plants.
منابع مشابه
Control of alternative pre-mRNA splicing by RNA Pol II elongation: faster is not always better.
The realization that the mammalian proteomic complexity is achieved with a limited number of genes demands a better understanding of alternative splicing regulation. Promoter control of alternative splicing was originally described by our group in studies performed on the fibronectin gene. Recently, other labs extended our findings to the cystic fibrosis, CD44 and CGRP genes strongly supporting...
متن کاملRegulation of alternative splicing through coupling with transcription and chromatin structure.
Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of genetic information from DNA to proteins by expanding the coding capacity of genomes. Regulation of alternative splicing is as important as regulation of transcription to determine cell- and tissue-specific features, normal cell functioning, and responses of eukaryotic cells to external cues. Its importa...
متن کاملRNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing
The elongation phase of transcription lies at the core of several simultaneous and coupled events leading to alternative splicing regulation. Although underestimated in the past, it is at this phase of the transcription cycle where complexes affecting the transcription machinery itself, chromatin structure, posttranscriptional gene regulation and pre-mRNA processing converge to regulate each ot...
متن کاملGene Silencing: Small RNAs Control RNA Polymerase II Elongation
Short interfering RNAs trigger histone silencing marks and stalling of RNA polymerase II at their genomic target sites through a mechanism termed transcriptional gene silencing (TGS). The Argonaute protein NRDE-3, along with NRDE-2, are needed for TGS in C. elegans. TGS also inhibits elongation and controls alternative splicing in mammalian cells.
متن کاملDNA Damage Regulates Alternative Splicing through Inhibition of RNA Polymerase II Elongation
DNA damage induces apoptosis and many apoptotic genes are regulated via alternative splicing (AS), but little is known about the control mechanisms. Here we show that ultraviolet irradiation (UV) affects cotranscriptional AS in a p53-independent way, through the hyperphosphorylation of RNA polymerase II carboxy-terminal domain (CTD) and a subsequent inhibition of transcriptional elongation, est...
متن کامل